Protein imaging at the speed of life

With this capability, scientists can watch how proteins do their jobs properly—or how their shape-changing goes awry, causing disease. NOVEMBER 18, 2019 by University of Wisconsin – Milwaukee To study the swiftness of biology—the protein chemistry behind every life function—scientists need to see molecules changing and interacting in unimaginably rapid time increments—trillionths of a second or […]

What survives, thrives and dominates over a thousand generations? The answer might be even more complex than thought

NOVEMBER 13, 2019 by Harvard University Aa team of scientists, led by Harvard researchers, has used a new method of DNA “re-barcoding” to track rapid evolution in yeast. The new approach, published in Nature, advances the field of organismic and evolutionary biology and holds promise for real-world results. The potential impact of the work can be illustrated […]

Biologists build proteins that avoid crosstalk with existing molecules

Engineered signaling pathways could offer a new way to build synthetic biology circuits. Anne Trafton | MIT News OfficeOctober 23, 2019 Inside a living cell, many important messages are communicated via interactions between proteins. For these signals to be accurately relayed, each protein must interact only with its specific partner, avoiding unwanted crosstalk with any […]

Cell stiffness may indicate whether tumors will invade

Study shows tumors with softer, larger cells at their periphery are more likely to spread; may suggest new route for cancer therapy. Jennifer Chu | MIT News OfficeOctober 21, 2019 Engineers at MIT and elsewhere have tracked the evolution of individual cells within an initially benign tumor, showing how the physical properties of those cells […]

Whitehead Institute team resolves structure of master growth regulator

New research reveals how mTORC1 docks at lysosomal surface. Nicole Davis | Whitehead InstituteOctober 18, 2019 A team of Whitehead Institute scientists has for the first time revealed the molecular structure of a critical growth regulator bound to its partner proteins, creating a fine-grained view of how they interact to sense nutrient levels and control […]

Drug that blocks blood vessel growth could treat rare sarcomas

An experimental targeted drug could treat a rare type of cancer usually affecting the limbs, a clinical trial led by The Institute of Cancer Research, London, has shown. OCTOBER 16, 2019 by Institute of Cancer Research The important trial could lead to a much-needed new treatment for patients with alveolar soft part sarcoma (ASPS), which tends […]

Study reveals how mucus tames microbes

Specialized sugar molecules called glycans can disarm opportunistic pathogens and prevent infection. Anne Trafton | MIT News OfficeOctober 14, 2019 More than 200 square meters of our bodies — including the digestive tract, lungs, and urinary tract — are lined with mucus. In recent years, scientists have found some evidence that mucus is not just […]

New method visualizes groups of neurons as they compute

Fluorescent probe could allow scientists to watch circuits within the brain and link their activity to specific behaviors. Anne Trafton | MIT News OfficeOctober 9, 2019 Using a fluorescent probe that lights up when brain cells are electrically active, MIT and Boston University researchers have shown that they can image the activity of many neurons […]